Biomarker

TOPO1

TOPO1, or topoisomerase I, is an enzyme that alters the supercoiling of double-stranded DNA. TOPO1 acts by transiently cutting one strand of the DNA to relax the coil and extend the DNA molecule. The regulation of DNA supercoiling is essential to DNA transcription and replication, when the DNA helix must unwind to permit the proper function of the enzymatic machinery involved in these processes.

Associated Signaling Pathways

Associated Treatments

Associated Tumor Types

Content provided for information purposes only and does not necessarily reflect the markers included in the Caris Molecular Intelligence Service. References on file and available upon request.