Biomarker

TLE3

TLE3, or transducin-like enhancer protein 3, is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorigenesis and classification of sarcomas. It is a transcriptional repressor involved in repressing epithelial cell fate determination. It interacts with the Notch/WNT pathway and appears to be periodically expressed during the M phase of the cell cycle.

Associated Signaling Pathways

Associated Treatments

Associated Tumor Types

Content provided for information purposes only and does not necessarily reflect the markers included in the Caris Molecular Intelligence Service. References on file and available upon request.