Biomarker

ERCC1

ERCC1, or excision repair cross-complementation group 1, is a component of the nucleotide excision repair (NER) pathway which is essential for the repair of platinum-induced DNA adducts. Consequently, overexpression of ERCC1 is associated with resistance to platinum-based therapies. In gastric cancer, relapsed NSCLC and ovarian cancer, low levels of ERCC expression may be associated with increased chemosensitivity to platinum-based therapies.

Associated Signaling Pathways

Associated Treatments

Associated Tumor Types

Content provided for information purposes only and does not necessarily reflect the markers included in the Caris Molecular Intelligence Service. References on file and available upon request.